September 2026 SCRI Release Notes Copied
Updates were completed between August 21, 2026 and September 17, 2026.
Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens.
For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 26022 | USOR 26022 MPN 33 Phase 2/3 Bomedemstat Q14D – 11JUN2026 USOR 26022 MPN 33 Phase 2/3 Ropeginterferon alfa-2b Q14D – 11JUN2026 USOR 26022 MPN 33 Phase 2/3 Ruxolitinib Q30D – 11JUN2026 |
| 26017 | USOR 26017 BRE 484 Phase 3 Abemaciclib + Letrozole Q28D – v3.0 30APR2026 USOR 26017 BRE 484 Phase 3 BGB-43395 + Letrozole Q28D – v3.0 30APR2026 USOR 26017 BRE 484 Phase 3 Palbociclib + Letrozole Q28D – v3.0 30APR2026 USOR 26017 BRE 484 Phase 3 Ribociclib + Letrozole Q28D – v3.0 30APR2026 |
| 25151 | USOR 25151 MULTI 107 Phase 1b IMGS-001 Q14D – v15.0 15JUN2026 |
| 24318 | USOR 24318 PRO 40 Phase 2 Telisotuzumab Adizutecan Q21D – v2.0 04MAR2026 |
| 25211 | USOR 25211 CLL 71 Phase 3 Arm A NX-5948 Q28D – v0.1 05MAY2026 USOR 25211 CLL 71 Phase 3 Arm B Pirtobrutinib Q28D – v0.1 05MAY2026 |
| 25180 | USOR 25180 GYN 170 Phase 3 Arm 1 Rinatabart Sesutecan +/- Bevacizumab Q21D – v1.0 15AUG2025 USOR 25180 GYN 170 Phase 3 Arm 2 Bevacizumab Q21D – v1.0 15AUG2025 |
| 26004 | USOR 26004 GI 455 Phase 1a Fluorouracil + Leucovorin + Oxaliplatin + Irinotecan (FOLFIRINOX) Q14D – v5.2 20APR2026 USOR 26004 GI 455 Phase 1a Fluorouracil + Leucovorin + Oxaliplatin + Irinotecan (mFOLFIRINOX) Q14D – v5.2 20APR2026 USOR 26004 GI 455 Phase 1a Fluorouracil + Leucovorin + Oxaliplatin + Liposomal Irinotecan (NALIRIFOX) Q14D – v5.2 20APR2026 USOR 26004 GI 455 Phase 1a IBI343 + Fluorouracil + Leucovorin + Oxaliplatin (mFOLFOX) Q14D – v5.2 20APR2026 |
| 25183 | USOR 25183 LUN 653 Phase 3 Intismeran + Pembrolizumab SQ Q42D – 15DEC2025 USOR 25183 LUN 653 Phase 3 Intismeran or Placebo Q21D – 15DEC2025 |
| RM 1406 MCCR |
RM 1406 Phase 1/1b SI-B036 Q21D – v2.0 28JUL2026 |
| GI 468 MCCR |
GI 468 Phase 1 XNW28012 Q21D – v1.1 18JUN2026 |
| 25201 | USOR 25201 MM 211 Phase 3 Arm A JNJ-79635322 (Step-Up Dose) – 23FEB2026 USOR 25201 MM 211 Phase 3 Arm A JNJ-79635322 Q28D – 23FEB2026 USOR 25201 MM 211 Phase 3 Arm B Teclistamab Q28D – 23FEB2026 |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Drug Service Order Information | Updated Regimen Instructions | Other Changes |
| RM 1359 MCCR |
Version 2.0; 26-June-2026 | N/A | N/A | Update drug; instructions |
| RM 1306 MCCR |
Version 4.0; 22-May-2026 PM v5.0; 10-July-2026 PM v6.0; 28-July-2026 |
N/A | N/A | Added Drug; Update Drug; Admin/Prep |
| 25238 | Version 3.0; 15-June-2026 | N/A | Regimen comments; Admin, Premedication | Update Drug; Admin/Prep |
| 25204 | Version 4.0; 15-April-2026 PM v5.0: 17-July-2026 |
N/A | Regimen Comments; Admin, Prophylaxis, Premedication | Closed Arm(s), New Arm(s), Update Drug; Supportive Care, Admin/Prep |
| 25204 | Memo; dated 03-June-2026 Memo; dated 03-June-2026 Memo; dated 05-June-2026 |
N/A | Regimen Comments; Admin | Update Drug; Dose/Form |
| 25137 | Version E; 22-May-2026 | N/A | Regimen Comments; Observation | Update Drug; Admin/Prep |
| 25123 | PM v2.0; 24-Aug-2026 | N/A | N/A | Updated Drug; Admin/Prep |
| 25042 | PM v4.0; 23-June-2026 | N/A | N/A | Update Drug; Dos/Form |
| 24316 | Version C; 01-June-2026 | N/A | N/A | Update Drug; Admin/Prep, New Arm(s) |
| 24279 | Version 4.0; 29-May-2026 | N/A | Regimen Comments; Observation | N/A |
| 24170 | PM v6.0; 07-July-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 24070 | Version 4.0; 26-May-2026; | N/A | N/A | Added: Drug Update Drug; Admin/Prep |
| 24059 | PA Version 4.0; 02-July-2026 PM Version 5.0; 23-Feb-2026 |
N/A | Regimen Comments; Observation, Premedication | Update Drug; Admin/Prep, Supportive Care |
| 23292 | Version 21.1; dated 21-May-2026 PM Version 13.0; 26 JUN 2026 | N/A | Regimen Comments; Prophylaxis | Update Drug; Dose/Form, Instructions |
| 23252 | Version 5.0; 08-December-2025 PM v4.0; 15-January-2026 |
N/A | Regimen Comments; Admin, Prophylaxis | Added: Drug, New Arm(s), Update Drug; Supportive Care |
| 25225 | PCL; dated 31-Aug-2026 | N/A | Regimen Comments; Prophylaxis | N/A |
| 23120 | Version 10.0; 12-Feb-2026 Version 10.1; 12-March-2026 PM v11.0; 02-Apr-2026 |
NA | Regimen Comments; Admin, Prophylaxis, Premedication | Update Drug; Admin/Prep, Supportive Care |
| 24100 | Admin Letter #6; dated 14-Aug-2026 | N/A | Regimen Comments; Prophylaxis, Premedication | Update Drug; Supportive Care, |
| 26056 | Procurement change | N/A | N/A | Update Drug; Procurement |
| RM 1263 MCCR |
Version 5.0; 30-April-2026 PM v2.0; 12-May-2026 |
N/A | Regimen Comments; Admin, Prophylaxis, Premedication | New Arm(s) Update Drug; Admin/Prep |
| 24265 | PM v7.0; 04-Sept-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 25080 | Version 2.0; 23-March-2026 | N/A | Regimen Comments; Admin, Prophylaxis | Added: Drug Update Drug; Admin/Prep |
| 22067 | PM v13.0; 19-Aug-2026 | N/A | N/A | Update Drug; Dose/Form |