September 2025 SCRI Release Copied
SCRI Trials and Trial Regimen Updates
The following updates were completed between Aug. 22 – Sept. 18. Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens.
For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 25018 | USOR 25018 GI 411 Phase 3 HLX22 or Placebo + Trastuzumab + Oxaliplatin + Capecitabine + Pembrolizumab or Placebo Q21D – v3.0 17DEC2024
USOR 25018 GI 411 Phase 3 HLX22 or Placebo + Trastuzumab + Oxaliplatin + Capecitabine Q21D – v3.0 17DEC2024 |
| 24321 | USOR 24321 LYM 260 Phase 3 Golcadomide + Rituximab Q28D – 11FEB2025
USOR 24321 LYM 260 Phase 3 Rituximab + Bendamustine Q28D – 11FEB2025 USOR 24321 LYM 260 Phase 3 Rituximab + CHOP Q21D – 11FEB2025 USOR 24321 LYM 260 Phase 3 Rituximab + Lenalidomide Q28D – 11FEB2025 |
| 24059 | USOR 24059 GYN 135 Phase 2 Part A R-DXd Q21D – v2.0 05FEB2025 |
| 24311 | USOR 24311 BRE 460 Phase 1 Safety Cohort A1 Sacituzumab govitecan Q14D – 19NOV2024 |
| 24094 | USOR 24094 BRE 457 Phase 3 Arm A PF-07220060 + Letrozole Q28D – 03SEP2024
USOR 24094 BRE 457 Phase 3 Arm B Letrozole + CDK4/6 Inhibitor Q28D – 03SEP2024 |
| 24185 | USOR 24185 BRE 448 Phase 3 Arm A sac-TMT (MK-2870) Q84D 22NOV2024
USOR 24185 BRE 448 Phase 3 Arm B sac-TMT (MK-2870) + Pembrolizumab Q84D 22NOV2024 USOR 24185 BRE 448 Phase 3 Arm C Gemcitabine + Carboplatin Q84D 22NOV2024 USOR 24185 BRE 448 Phase 3 Arm C Nab-paclitaxel Q84D 22NOV2024 USOR 24185 BRE 448 Phase 3 Arm C Paclitaxel Q84D 22NOV2024 |
| 24266 | USOR 24266 CLL 65 Phase 3 Arm A Sonrotoclax + Obinutuzumab Q28D – 13FEB2025
USOR 24266 CLL 65 Phase 3 Arm B Sonrotoclax + Rituximab Q28D – 13FEB2025 USOR 24266 CLL 65 Phase 3 Arm C Sonrotoclax + Obinutuzumab Q28D – 13FEB2025 USOR 24266 CLL 65 Phase 3 Arm D Venetoclax + Rituximab Q28D – 13FEB2025 |
| 24232 | USOR 24232 LUN 581 Phase 3 Arm A NVL-655 Q28D – v2.0 06JUN2025
USOR 24232 LUN 581 Phase 3 Arm B Alectinib Q28D – v2.0 06JUN2025 |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Regimen Instructions | Other Changes |
| 24326 | PM v3.0 29Apr2025 | Regimen Comments; Admin and Observation | Updated Drug Instructions |
| 24312 | PA 2.0; 25 July 2025 | Regimen Comments: Admin | Updated Drug Instructions and Premedication |
| 24312 | PM v1.1 04Mar2025 | N/A | Updated drug; Admin and Prep |
| 24288 | PM v1.0; 20 August 2025 | N/A | Updated drug instructions |
| 24169 | PA 2, 14APRIL2025 | Regimen Comments: Admin | Updated Drug Instructions |
| 24150 | PCL; 01 August 2025
PCL; 11 August 2025 |
N/A | Updated drug frequency |
| 24030 | Version 3.0; 01 July 2025 | Regimen comments; Admin | Updated drug instructions and premedication |
| 23340 | PM v5.0; 13 August 2025 | N/A | Updated Dose/Form and instructions |
| 23328 | Version 2.0; 03MAR2025 | N/A | Updated drug instructions |
| 23302 | PM v2.0; 16th April 2025 | N/A | Updated drug instructions |
| 23245 | DIL; 27 August 2025 | N/A | New arms |
| 23180 | PA v3.0, 27May2025 | Regimen Comments; Observation | Updated drug instructions and premedication |
| 23166 | DIL; 14 August 2025 | N/A | Closed arms |
| 23116 | Amendment v6, 29APR2025 | Regimen Comments: Admin | Updated Admin/Prep and drug instructions |
| 23084 | PM v3.0; 21st August 2025 | N/A | Updated Drug instructions |
| 22242 | Version 6.0, 02MAY2025 | N/A | Updated drug; instructions, premedication, and frequency |
| 22095 | PA v9.0: 01 May 2025 | Regimen comments: Admin | Updated drug instructions |
| 22026 | PA8: 25 Feb 2025 | Regimen comments: Admin, Prophylaxis, Premedication | Updated drug; instructions and premedication |
| 22026 | Version 7.0; 07 August 2025 PACL; 11 August 2025 | Regimen Comments; Admin and Observation | Updated drug; Drug form, instructions, premedication, procurement |
| 24326 | Amendment 1 Version 2; 19MAR2025. | Regimen comments; admin | Updated drug; premedication
New Arms |
| 24259 | PM v2.0; 13th Feb 2025 | N/A | Updated drug; predication |
| 23292 | PA v18.0; 24 Feb 2025 | Regimen Comments; Admin | Updated drug; premedication
New arms |
| 24130 | PCL; 16 June 2025
PA v4.0; 26 June 2025 |
N/A | Updated drug instructions and premedication |