• Infuse using an in-line or add-on filter (0.2 to 0.22 micron).
• Gently invert to mix. Do not shake. Do not give IV push or bolus. Do not administer with other drugs.

New default SIG:

• 1,200 mg intravenously Piggyback once; administer over 60 minutes; admixture fluid 250 ml

New Maximum Single Dose:

• 1,200 mg

• 1 patch transdermally every 72 hours. Dispense 3 Patch, quantity sufficient for 10 days

Available SIG option for 10 patches/30 days:

• Fentanyl Patch 1 patch transdermally every 72 hours; quantity sufficient for 30 days

Note: The option for 10 patches per 30 days will be available, and practices can set this as the default at their practice level, if desired.

• Fentanyl Patch 1 patch transdermally every 72 hours; quantity sufficient for 30 days

Note: The option for 10 patches per 30 days will be available, and practices can set this as the default at their practice level, if desired.

• Therapeutic

Removed SIGs:

• 0 mg orally daily
• 0 mg orally daily; Should be taken orally once daily on an empty stomach—no food for at least 2 hours before and 1 hour after dosing. Take at the same time each day with water only (no caffeine). Swallow tablets whole; do not chew, cut, or crush; quantity
• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed

• 30 mg capsule (also for Research)

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed
• 0 mg orally 2 times per day
• 50 mg orally daily
• 75 mg orally daily
• 100 mg orally daily

• 0 mcg/kg intravenously once; Dilute with 0.9% Sodium Chloride to a final concentration of 0.02-0.8 mg/mL. Administer through 0.2-5.0 um in-line filter. Do not shake the vial

New Form available:

• 60 mg/6 mL (10 mg/mL) solution (also for Research)

• 395 mg subcutaneously once

• 790 mg subcutaneously once

• 1 % drops,suspension
• New Quick SIG Pick available:
• 1 drop into the eye(s) 4 times per day
• 1 drop into the eye(s) 6 times per day
• 1 drop into the eye(s) As Directed
• 1 drop into the eye(s) every hour

New SIGs with Dose Cap:

• Tocilizumab 8 mg/kg intravenously Piggyback once; For COVID-19 (SIG contains dose override setting)
• Tocilizumab 8 mg/kg intravenously Piggyback once; For Cytokine Release Syndrome (SIG contains dose override setting)
• Tocilizumab 8 mg/kg intravenously Piggyback once; For Giant Cell Arteritis (SIG contains dose override setting)
• Tocilizumab 6 mg/kg intravenously Piggyback once; For Rheumatoid Arthritis (SIG contains dose override setting)

• Tocilizumab-anoh 8 mg/kg intravenously Piggyback once; For COVID-19 (SIG contains dose override setting)
•  Tocilizumab-anoh 8 mg/kg intravenously Piggyback once; For Cytokine Release Syndrome (SIG contains dose override setting)
• Tocilizumab-anoh 8 mg/kg intravenously Piggyback once; For Rheumatoid Arthritis  (SIG contains dose override setting)
• Tocilizumab-anoh 6 mg/kg intravenously Piggyback once; For Giant Cell Arteritis (SIG contains dose override setting)

• Tocilizumab-anoh 8 mg/kg intravenously Piggyback once; For COVID-19 (SIG contains dose override setting)
• Tocilizumab-anoh 8 mg/kg intravenously Piggyback once; For Cytokine Release Syndrome (SIG contains dose override setting)
• Tocilizumab-anoh 8 mg/kg intravenously Piggyback once; For Rheumatoid Arthritis  (SIG contains dose override setting)
• Tocilizumab-anoh 6 mg/kg intravenously Piggyback once; For Giant Cell Arteritis (SIG contains dose override setting)

New Instructions:

• Dilute to a total volume of 100 mL for patients 30 kg or greater or 50 mL for patients less than 30 kg.  Gently invert to mix. Do not shake. Allow diluted solution to warm to room temperature prior to infusion. Do not give IV push or bolus. Do not administer with other drugs. Monitor for infusion reactions. Note: This is Avtozma.

• Tocilizumab-bavi 8 mg/kg intravenously Piggyback once; For COVID-19 (SIG contains dose override setting)
• Tocilizumab-bavi 8 mg/kg intravenously Piggyback once; For Cytokine Release Syndrome (SIG contains dose override setting)
• Tocilizumab-bavi 8 mg/kg intravenously Piggyback once; For Rheumatoid Arthritis (SIG contains dose override setting)
• Tocilizumab-bavi 6 mg/kg intravenously Piggyback once; For Giant Cell Arteritis (SIG contains dose override setting)

No Maximum Single Dose is set.

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed

Removed Instructions:

•  Take at the same time daily. Swallow whole—do not chew, crush, or split. Do not retake if vomiting occurs. Follow patient guidelines provided.

Gallbladder Cancer;

Melanoma, Skin;

Renal Cell Carcinoma (RCC);

Uterine Cancer (Parent)

Uterine Cancer (Parent)

D1,22 Q42D

• 2 mg
• 2000 mcg

• 2 mg
• 2000 mcg

• 2.4 mL
• 395 mg

• 4.8 mL
• 790 mg

• [177Lu] Lu-DOTA-TATE invest IV

Removed SIGs:

• 0 GBq intravenously once
• 0 MBq intravenously once
• 200 mCi intravenously once
• 7.4 GBq intravenously As Directed; administer 4 times every 8 (+/-1) weeks

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 MBq/kg intravenously As Directed
• 0 MBq/m2 intravenously As Directed
• 0 mCi/kg intravenously As Directed
• 0 mCi/m2 intravenously As Directed
• 0 mCi intravenously every 8 weeks
• 0 MBq intravenously every 8 weeks

• 107.5 lyophilized powder for injection vial

Removed SIGs:

• 0 mg/mkg intravenously As Directed
• 0 mg/m2 intravenously As Directed
• 0 mL intravenously once

Removed Instructions:

• Administer 30 minutes (+/- 5 minutes)

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

Removed Formula Units:

• mg/kg
• mg/m2

• This product is light sensitive upon reconstitution and dilution. All precautions must be taken to limit light exposure after reconstitution. During infusion, infusion bag covers must be implemented.

Removed SIGs:

• 0 mg/m2 intravenously As Directed
• 0 mg intravenously every 28 days

• 100 mg lyophilized powder vial

Removed SIGs:

• 0 mg/kg intravenously once; Administer over approximately 30 minutes once every 21 days (Q21D). ABBV-399 must be refrigerated at 2 to 8 degrees C/36 to 46 degree Fahrenheit, protected from light
• 0 mg/kg intravenously once

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg intravenously Infusion (Drip) every 3 weeks
• 0 mg/kg intravenously Piggyback once
• 0 mg intravenously Piggyback every 4 weeks
• 0 mg intravenously Infusion (Drip) every 2 weeks
• 0 mg intravenously As Directed

• Administer over 120 +/- 15 minutes.

Removed SIG:

• 0 mg/m2 intravenously once; administer over 120 +/- 15 minutes.

Removed Formula Units:

• mg/kg

• 0 mg/kg intravenously once
• 0 mg/m2 intravenously As Directed
• 0 mg intravenously once

• 0 mg/kg orally daily
• 0 mg/m2 orally daily
• 0 mg orally daily
• 0 mg orally 2 times per day

• 0 mg intravenously once
• 0 mcg/kg intravenously once
• 0 mcg/m2 intravenously once
• 0 mcg intravenously As Directed

Removed Instructions:

• DO NOT administer APVO436 as an intravenous bolus or subcutaneously. Infuse over 4 hours

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg intravenously every 2 weeks
• 0 mg/m2 intravenously every 2 weeks
• 0 mg intravenously As Directed

• 0 mg/day orally daily
• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

•  0 mg/kg intravenously every 21 days; Dilute to a final concentration of 0.5 mg/mL to 6 mg/mL. 1st infusion over about 90 minutes; if no infusion reactions, subsequent infusions may be given over 30 to 60 minute IV infusion.; admixture fluid 0 ml of Dextro
• 0 mg/kg intravenously every 28 days; Dilute to a final concentration of 0.5 mg/mL to 6 mg/mL. 1st infusion over about 90 minutes; if no infusion reactions, subsequent infusions may be given over 30 to 60 minute IV infusion.; admixture fluid 0 ml of Dextro
  • 0 mg/kg intravenously once
  • 0 mg intravenously once
  • 0 mg/m2 intravenously As Directed

• 0 mg intravenously As Directed
• 0 mg/kg intravenously every 3 weeks
• 0 mg/m2 intravenously once

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• 0 mg/kg intravenously once
• 0 mg intravenously once

• 0 mg intravenously once; administer over 120 minutes (-10/+20 min); admixture fluid 250 ml
• 0 mg/kg intravenously once
• 0 mg/m2 intravenously once

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg intravenously once
• 0 mg/m2 intravenously As Directed
• 0 mg intravenously every 3 weeks; administer over 60 min (-5 min/+10 min)

• Administered intravenously for 120 min (+/-10 min). If no infusion reaction occurred during the first administration, the drug could be administrated between 60-120 min during subsequent cycles.
• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg intravenously once
• 0 mg/m2 intravenously As Directed

• 0 mg/kg orally daily
• 0 mg/m2 orally As Directed

• Take with or without food.

Removed SIGs:

• 0 mg/kg orally daily
• 0 mg/m2 orally daily
• 0 mg orally daily
• 0 mg orally As Directed

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg intravenously once
• 8 mL intravenously every 28 days
• 8 mL intravenously every 4 weeks

• 0 mg intravenously once
• 0 mg/kg intravenously As Directed
• 0 mg/m2 intravenously As Directed

• 0 mg orally daily; Take with at least 240 mL (8 oz) of water. Swallow whole; do not chew.
• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed

• 0 mg/m2 intravenously As Directed
• 0 mg/kg intravenously once
• 0 mg intravenously once

• 0 mg intravenously every 3 weeks
• 0 mg/kg intravenously every 3 weeks
• 0 mg/m2 intravenously As Directed

New SIG:

• 3 mg/kg intravenously once

• 0 mg/kg intravenously once
• 0 mg/m2 intravenously once

• x 10e6 viable CARpos cells

New SIGs:

• 13 x 10e6 cells/mL intravenously once
• 40 x 10e6 cells/mL intravenously once
• 60 x 10e6 cells/mL intravenously once
• 80 x 10e6 cells/mL intravenously once
• 120 x 10e6 cells/mL intravenously once
• 360 x 10e6 cells/mL intravenously once

• 0 mg/kg orally once
• 0 mg/m2 orally once
• 0 mg orally daily
• 0 mg orally once

• Do not shake.
• Admixture fluid 0.9 % Sodium Chloride

Removed SIGs:

• 0 mg/kg intravenously once
• 0 mg/m2 intravenously once
• 0 mg intravenously every 21 days
• 0 mg intravenously every 3 weeks

• Administer over 30 (+/- 5) minutes.

Removed SIGs:

• 0 mg/m2 intravenously once
• 0 mg intravenously As Directed

• 0 mg/kg orally 2 times per day
• 0 mg/m2 orally 2 times per day

• 200 mg/vial

Removed SIGs:

• 0 mg/kg intravenously every 21 days
• 0 mg/kg intravenously every 3 weeks

• Take whole with a 6 oz (180 mL) glass of water.

Removed SIGs:

• 0 mg/kg orally As Directed
• 0 mg/m2 orally every week
• 0 mg orally 2 times per week

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Updated Form from 120 mg recon soln to:

• 120 mg/vial

Removed SIGs:

• 0 mg/kg intravenously every 28 days
• 0 mg/m2 intravenously every 4 weeks
• 0 mg intravenously once

• 100mg/ lyophilized powder/ vial

Removed SIGs:

• 0 mg/m2 intravenously As Directed
• 0 mg/kg intravenously Piggyback once
• 0 mg/kg intravenously Infusion (Drip) once
• 0 mg/mg intravenously As Directed
• 0 mg intravenously once

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg intravenously every 4 weeks
• 0 mg/m2 intravenously every 2 weeks

• 0 mg/kg orally 2 times per day
• 0 mg/m2 orally 2 times per day

• 0 mg/kg orally daily
• 0 mg/m2 orally daily
• 0 mg orally daily
• 0 mg orally As Directed

• 0 mg/kg intravenously As Directed
• 0 mg/m2 intravenously As Directed

• 0 mg/m2 intravenously every 3 weeks
• 0 mg/kg intravenously every 3 weeks
• 0 mg intravenously once

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg intravenously once
• 0 mg/m2 intravenously As Directed
• 0 mg intravenously once
• 15 mg/kg intravenously every 3 weeks

New SIG:

• 15 mg/kg intravenously once

• 0 mg/m2 orally As Directed
• 0 mg/kg orally As Directed

• 0 mg intramuscularly once
• 0 mg orally once
• 0 kits orally As Directed

New Instructions available:

• Each kit includes: Hydrocortisone 10 mg tablets (1 bottle of 100 tablets) and hydrocortisone 100 mg powder and solution (for IM injection).

Removed Routes:

• Orally
• Intramuscularly

New Route:

• As directed

• 0 mg/m2 intravenously once
• 0 mg/kg intravenously every 2 weeks
• 0 mg/m2 intravenously every 3 weeks

Updated Form:

• Lyophilized powder

Removed Instructions:

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

• Intratumoral

Removed Instructions:

• Refer to Pharmacy Manual for preparation instructions.

Updated Form:

• Kit (2 vials/kit); Vial 1: pAc/emm55 0.6 mg/0.3 mL soln and Vial 2: in vivo-jetPEI 1.71 mg/0.6 mL soln = Final Vial IFx-Hu2.0 0.6mg/1.2 mL

Removed SIG:

• 1.2 mL intralesionally As Directed

New SIG:

• 0.2 mL intratumorally once

• 0 x 10e11 vp intravenously every 3 weeks
• 0 x 10e12 vp intravenously once
• 1 x 10e11 vp intravenously once
• x 10e11 vp intravenously once
• 3.3 x 10e11 vp intravenously once

Added SIGs:

• 1 x 10e11 intravenously once
  • x 10e11 intravenously once
• 3.3 x 10e11 intravenously once
• 1 x 10e12 intravenously once
  • x 10e12 intravenously once
• 3.3 x 10e12 intravenously once

Removed Instructions:

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

• 0 mg intravenously As Directed
• 0 mg/kg intravenously once
• 0 mg/m2 intravenously once

Updated Form:

• mg/vial

Removed Instructions:

• Do not shake. See Pharmacy Manual for preparation, handling, and administration, observation guidance.

• Swallow whole with food.

Removed SIGs:

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed
• 0 mg orally daily

New SIG:

• 200 mg orally daily

• 0 mg intravenously As Directed
• 0 mg/kg intravenously once
• 0 mg/m2 intravenously once

Updated Form:

• mg/vial

Removed Instructions:

• Do not shake. See Pharmacy Manual for preparation, handling, and administration, observation guidance.

• 0 mL intratumorally once
• 0 x 10e9 pfu intratumorally once
• 0 x 10e9 pfu/mL intratumorally once

Added SIG:

• 2 mL intratumorally once

• Anitocabtagene Autoleucel invest IV

Updated Form from 10-15 cryostorage bag to:

• Cryostorage bag

Removed Instructions:

• Must be administered through dimethyl sulfoxide (DMSO) compatible IV tubing.
• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

• 0 mg/kg orally daily
• 0 mg/m2 orally daily
• 0 mg orally As Directed
• 0 mg orally daily

• 0 mg orally daily
• 140 mg orally 2 times per day; For BID dosing schedule, take doses approximately 12 hours apart.
• 20 mg orally 2 times per day; For BID dosing schedule, take doses approximately 12 hours apart.
• 200 mg orally 2 times per day; For BID dosing schedule, take doses approximately 12 hours apart.
• 300 mg orally 2 times per day; For BID dosing schedule, take doses approximately 12 hours apart.
• 40 mg orally 2 times per day; For BID dosing schedule, take doses approximately 12 hours apart.
• 400 mg orally 2 times per day; For BID dosing schedule, take doses approximately 12 hours apart.
• 800 mg orally 2 times per day; For BID dosing schedule, take doses approximately 12 hours apart.

New SIGs:

• 40 mg orally daily
• 80 mg orally daily
• 140 mg orally daily
• 200 mg orally daily
• 300 mg orally daily
• 400 mg orally daily
• 6 mg orally 2 times per day
• 12 mg orally 2 times per day
• 20 mg orally 2 times per day
• 40 mg orally 2 times per day
• 80 mg orally 2 times per day
• 140 mg orally 2 times per day
• 200 mg orally 2 times per day
• 300 mg orally 2 times per day
• 400 mg orally 2 times per day

Removed Instructions:

• To be taken at same time each day with water. Take under fasting conditions, at least 2 hours before and 1 hour after dose.

• 0 mg/kg orally 2 times per day
• 0 mg/m2 orally 2 times per day

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• Must not be taken with antacids or with food.

Removed SIGs:

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• 0 mg/kg orally 2 times per day
• 0 mg/kg orally As Directed
• 0 mg/kg orally daily

• 0 mg/kg orally 2 times per day
• 0 mg/m2 orally As Directed
• 0 mg orally daily

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• 0 mg/kg orally As Directed
• 0 mg/m2 orally once

• 0 mg/kg intravenously As Directed
• 0 mg/m2 intravenously once
• 0 mg intravenously once

• 0 mg/m2 intravenously ever 3 weeks

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIG:

• 0 mg subcutaneously As Directed

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed
• 0 mg orally daily

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed
• 0 mg orally daily

• 0 mg/kg intravenously As Directed
• 0 mg intravenously As Directed

• Administer over a minimum of 2 hours (+/- 20 minutes). See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/m2 intravenously As Directed
• 0 mg/kg intravenously every week
• 0 mg intravenously every 3 weeks

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Updated Form to:

• 20 mg/mL vial
• 2 mg/mL vial

Removed SIGs:

• 0 mg/kg intravenously once
• 0 mg/m2 intravenously once
• 0 mg intravenously once

• Refer to dose preparation table in the pharmacy manual.

Removed SIGs:

• 0 mg/kg intravenously As Directed
• 0 mg/m2 intravenously As Directed
• 0 mL intravenously every 3 weeks
• 0 mg intravenously Infusion (Drip) every 21 days
• 0 mg intravenously Infusion (Drip) every 3 weeks

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg intravenously As Directed
• 0 mg/m2 intravenously As Directed
• 0 mg intravenously once

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg intravenously every 21 days
• 0 mg intravenously every 3 weeks

• 750 mg/vial (50 mg/mL)

Removed SIGs:

• 0 mg intravenously As Directed
• 0 mg intravenously once
• 0 mg/kg intravenously once
• 0 mg/m2 intravenously once

• Take with food and with approximately 240 mL (8 oz) of water.

Removed SIGs:

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed
• 0 mg orally 2 times per day

• 0 mcg/kg intravenously As Directed
• 0 mcg/m2 intravenously As Directed

Removed Instructions:

• See Pharmacy Manual for preparation, handling, administration, and observation guidance.

• 0 mg/kg orally daily
• 0 mg/m2 orally daily
• 0 mg orally daily

• The maximum volume of VO to be injected into any patient on any injection day will be 10 mL.

• 0 MBq/kg intravenously once
• 0 kBq intravenously once
• 0 kBq/kg intravenously once
• 0 uCi intravenously once
• 0 uCi intravenously every 6 weeks
• 0 uCi/kg intravenously once

• 0 mg/m2 intravenously once

• Take with food

Removed SIGs:

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed

• 0 mg/m2 intravenously once
• 0 mg/kg intravenously once
• 0 mg/kg intravenously every 3 weeks
• 0 mg/kg intravenously every 4 weeks
• 0 mg/kg intravenously As Directed
• 0 mg intravenously once

• 1.8 mg/kg AIBW intravenously once

• 10 mg/mL vial

Removed SIGs:

• 0 mg/m2 intravenously once
• 0 mg/kg intravenously every 2 weeks
• 0 mg/kg intravenously every 3 weeks
• 0 mg/kg intravenously every 6 weeks
• 0 mg intravenously As Directed

• 10 mg/mL solution
• 100 mg lyophilized powder

• 2ml vials = 1 kit

Removed Instructions:

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg subcutaneously once
• 0 mg/m2 subcutaneously once
• 0 kits subcutaneously once
• 600 mg subcutaneously every week

• 0 mg/kg orally As Directed
• 0 mg/m2 orally As Directed

• 0 mg/kg orally As Directed
• 0 mg/m2 orally 2 times per day

• Administer via a 30 minute (+/- 10 min) IV infusion

Removed SIGs:

• 0 mg/kg intravenously every 3 weeks
• 0 mg/m2 intravenously As Directed
• 0 mg intravenously once

• To be taken at same time each day with water. Take under fasting conditions, at least 2 hours before and 1 hour after dose. For BID dosing schedule, take doses approximately 12 hours apart.

• 0 mg/kg orally daily
• 0 mg/m2 orally daily

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Updated Form from 60 mg recon soln to:

• 60 mg/10 mL lyophilized powder

Removed SIGs:

• 0 mg/kg intravenously every 21 days; administer over 30 minutes
• 0 mg/m2 intravenously As Directed
• 0 mg intravenously As Directed

• 0 mL intravenously once
• 0 vials intravenously once
• 0 x 10e10 vg/kg intravenously once
• 0 x 10e11 vg/kg intravenously once
• 0 x 10e12 vg/kg intravenously once

Removed Instructions:

• Administer over 60-75 minutes

Updated Form:

• 4.56×10^12 vg/mL per 2.3 mL vial

• 0 mg/kg orally daily
• 0 mg/m2 orally As Directed

• Withdraw required amount directly from glass vial via syringe of appropriate sizing. Administration amount will depend on longest lesion diameter. No requirement for reconstitution.
• The maximum volume of VO to be injected into any patient on any injection day will be 10 mL. The maximum concentration of VO to be injected into any patient will be 1 × 107 PFU/mL (nominal).

Updated Instructions:

• Withdraw required amount directly from glass vial via syringe of appropriate sizing. Administration amount will depend on longest lesion diameter. No requirement for reconstitution. Maximum concentration injected into any patient will be 1×10^7 PFU/mL.

• Tablets can be taken whole with approximately 240 mL water without food (at least 60 minutes before food and at least 2 hours after food).

Removed SIGs:

• 0 mg/kg orally As Directed
• 0 mg/m2 orally daily

• Administer by IV infusion over 15 minutes via syringe pump.

Removed SIGs:

• 0 mg/kg intravenously As Directed
• 0 mg/m2 intravenously As Directed

Removed Frequency:

• Every 2 weeks

Updated Form from 30 mg recon soln to:

• 30 mg lyophilized powder

• See Pharmacy Manual for preparation, handling, and administration, observation guidance.

Removed SIGs:

• 0 mg/kg intravenously every 3 weeks; administer over 60 minutes (+/- 10 mins)
• 0 mg/m2 intravenously once
• 0 mg intravenously As Directed
• 2 mg/kg intravenously once

New SIG available:

• 1.2 mg/kg intravenously once