November 2024 SCRI Release Copied
SCRI Trials and Trial Regimen Updates
The following updates were completed between Oct. 21, 2024, through Nov. 14, 2024. Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens. For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 23133 | USOR 23133 | BRE 374 | Phase 3 Capivasertib, Ribociclib (D1-21), and Fulvestrant Q28D
USOR 23133 | BRE374 | Phase 3 Capivasertib, Palbociclib (D1-21), and Fulvestrant Q28D USOR 23133 | BRE374 | Phase 3 Control Arm Palbociclib (D1-21) and Fulvestrant Q28D USOR 23133 | BRE374 | Phase 3 Control Arm Ribociclib (D1-21) and Fulvestrant Q28D |
| 23225 | USOR 23225 CLL 57 Arm A Sonrotoclax + Zanubrutinib Q28D
USOR 23225 CLL 57 Arm B Venetoclax + Obinutuzumab Q28D |
| 24045 | USOR 24045 GI 374 Phase 2/3 Stage 1 Cohort 1 Livmoniplimab + Budigalimab Q21D
USOR 24045 GI 374 Phase 2/3 Stage 1 Cohort 2 Livmoniplimab + Budigalimab Q21D USOR 24045 GI 374 Phase 2/3 Stage 1 Cohort 3 Atezolizumab + Bevacizumab Q21D USOR 24045 GI 374 Phase 2/3 Stage 1 Cohort 3 Tremelimumab + Durvalumab fb Durvalumab Q28D |
| 24010 | USOR 24010 CLL 58 Phase 2 Venetoclax + Zanubrutinib Q28D
USOR 24010 CLL 58 Phase 2 Venetoclax + Ibrutinib Q28D USOR 24010 CLL 58 Phase 2 Venetoclax + Acalabrutinib Q28D |
| 23240 | USOR 23240 GU 235 Phase 3 Arm 1 MK-5684 + Fludrocortisone + Dexamethasone Q28D
USOR 23240 GU 235 Phase 3 Arm 2 Abiraterone Acetate + Prednisone Q28D USOR 23240 GU 235 Phase 3 Arm 2 Enzalutamide Q28D |
| 23029 | USOR 23029 RM 945 Phase 1b/2 MRTX092 Q21D
USOR 23029 RM 945 Phase 1b/2 MRTX092 + Adagrasib Q21D |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Regimen Instructions | Other Changes |
| 23292 | Protocol Version 17.0: 23 May 2024 | NA | New regimens added |
| 21468 | Amendment 05: 28 Aug. 2024 | NA | NA |
| 23025 | Version 8.0: 06 Sept. 2024 | NA | NA |
| 22041 | Version 4.0: 11 July 2024 | NA | NA |
| 19143 | Amendment 5: 20 March 2024 | NA | New regimen added |
| 23235 | Version 3.0: 05 Aug. 2024 | BSA calculation method updated | Change in IP admin schedule |
| 20266 | Version 6.0: 14 Aug. 2024 | NA | New regimens activated |
| 24089 | Version 4: 10 Oct. 2014 | NA | NA |