June 2026 SCRI Release Notes Copied
The following updates were completed between May 15, 2026 – June 18, 2026. Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens.
For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 25005 | USOR 25005 MDS 37 Phase 3 Lisaftoclax or Placebo + Azacitidine Q28D – v1.5 21FEB2025
USOR 25005 MDS 37 Phase 3 Ramp-up Lisaftoclax or Placebo D-2,-1 – v1.5 21FEB2025 |
| 25148 | USOR 25148 LYM 276 Phase 3 Rituximab + Gemcitabine + Oxaliplatin Q21D – 09APR2025
USOR 25148 LYM 276 Phase 3 Zilovertamab Vedotin + Rituximab + Gemcitabine + Oxaliplatin Q21D – 09APR2025 |
| 26014 | USOR 26014 GU 314 Phase 1b Xaluritamig (Step-Up and Target Dosing) Q28D – v1.0 02FEB2026 |
| RM 1319
MCCR |
RM 1319 Phase 1 TAK-505 Lead-In Dose Cohorts Q7D – 25FEB2026
RM 1319 Phase 1 TAK-505 Q28D – 25FEB2026 |
| 25089 | USOR 25089 MM 206 Phase 2 Group A Belantamab Mafodotin + Pomalidomide + Dexamethasone Q56D – 18DEC2025
USOR 25089 MM 206 Phase 2 Group A Belantamab Mafodotin + Pomalidomide + Dexamethasone Q84D – 18DEC2025. USOR 25089 MM 206 Phase 2 Group B Belantamab Mafodotin + Bortezomib + Dexamethasone Q56D – 18DEC2025 USOR 25089 MM 206 Phase 2 Group B Belantamab Mafodotin Q84D – 18DEC2025 USOR 25089 MM 206 Phase 2 Group C Belantamab Mafodotin + Carfilzomib + Dexamethasone Q56D – 18DEC2025 USOR 25089 MM 206 Phase 2 Group C Belantamab Mafodotin + Carfilzomib + Dexamethasone Q84D – 18DEC2025 |
| GU 308
MCCR |
GU 308 Phase 1 Part 1 JANX014 Schedule A Q21D – v2.0 13JAN2026
GU 308 Phase 1 Part 1 JANX014 Schedule B (C1-C2) Q21D – v2.0 13JAN2026 GU 308 Phase 1 Part 1 JANX014 Schedule B (C3+) Q28D – v2.0 13JAN2026 GU 308 Phase 1 Part 1 JANX014 Schedule C Q21D – v2.0 13JAN2026 |
| 24195 | USOR 24195 LUN 607 Phase 3 Adagrasib or Placebo + Pembrolizumab + Pemetrexed + Carboplatin Q21D – 20JUN2025
USOR 24195 LUN 607 Phase 3 Adagrasib or Placebo + Pembrolizumab + Pemetrexed + Cisplatin Q21D – 20JUN2025 USOR 24195 LUN 607 Phase 3 Maintenance Adagrasib or Placebo + Pembrolizumab + Pemetrexed Q21D – 20JUN2025 |
| 25187 | USOR 25187 GI 436 Phase 1/1b Divarasib + Bevacizumab + 5-Fluorouracil + Leucovorin + Irinotecan (FOLFIRI) Q28D – v8 16OCT2025
USOR 25187 GI 436 Phase 1/1b Divarasib + Bevacizumab + 5-Fluorouracil + Leucovorin + Oxaliplatin (mFOLFOX6) Q28D – v8 16OCT2025 |
| GYN 176
MCCR |
GYN 176 Phase 1a Part A HWK-016 Q21D – v3.0 27FEB2026
GYN 176 Phase 1a Part B HWK-016 + Bevacizumab Q21D – v3.0 27FEB2026 |
| 25163 | USOR 25163 GI 431 Phase 3 Arm A Daraxonrasib Q28D – v2.0 19FEB2026
USOR 25163 GI 431 Phase 3 Arm B Gemcitabine + Nab-Paclitaxel + Daraxonrasib fb Daraxonrasib Q28D – v2.0 19FEB2026 USOR 25163 GI 431 Phase 3 Arm C Gemcitabine + Nab-Paclitaxel Q28D – v2.0 19FEB2026 |
| BRE 472
MCCR |
BRE 472 Phase 1 IEV407 Q28D – v01 02APR2026
BRE 472 Phase 1b IEV407 + Fulvestrant Q28D – v01 02APR2026 BRE 472 Phase 1b IEV407 + Letrozole Q28D – v01 02APR2026 |
| 25141 | USOR 25142 GU 298 Phase 3 Safety Lead-In Vepugratinib + Enfortumab vedotin-ejfv + Pembrolizumab Q21D – 01Aug2025
USOR 25142 GU 298 Phase 3 Vepugratinib or Placebo + Enfortumab vedotin-ejfv + Pembrolizumab Q21D – 01Aug2025 |
| 26006 | USOR 26006 MISC 63 Adagrasib Q21D – 22DEC2025 |
| 25229 | USOR 25229 GI 448 Phase 2 Fluorouracil + Leucovorin + Irinotecan + Oxaliplatin (mFOLFIRINOX) Q28D – v1.0 17DEC2025
USOR 25229 GI 448 Phase 2 Telisotuzumab Adizutecan + Fluorouracil + Leucovorin + Oxaliplatin (FOLFOX) Q28D – v1.0 17DEC2025 |
| GU 300
MCCR |
GU 300 Phase 1 Part 1A Arm A INR731 Q28D – v02 13MAR2026
GU 300 Phase 1 Part 2A Arm B INR731 + Enzalutamide Q28D – v02 13MAR2026 GU 300 Phase 1 Part 2A Arm C INR731 + Abiraterone Q28D – v02 13MAR2026 |
| 25140 | USOR 25140 GI 424 Phase 3 Ivonescimab or Bevacizumab + 5-Fluorouracil + Leucovorin + Oxaliplatin (mFOLFOX6) Q14D – 27AUG2025
USOR 25140 GI 424 Phase 3 Maintenance Ivonescimab or Bevacizumab + 5-Fluorouracil + Leucovorin Q14D – 27AUG2025 |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Drug Service Order Information | Updated Regimen Instructions | Other Changes |
| 24260 | Version 4.0; 27-April-2026 | N/A | Regimen comments; administration, prophylaxis premedication | Update drug; instructions |
| 24314 | PA Version 2.0; 17-November-2025 | N/A | Regimen comments; administration, observation, premedication | Update drug; instructions |
| 21320 | Version 11.0; 01-April-2026 | N/A | Regimen comments; administration, observation, premedication | Update drug; instructions |
| 24251 | PA v2.0: 22 Dec 2025 | N/A | Regimen comments; premedication | Update drug; instructions |
| 23165 | Version 3.0; 15-April-2025 | N/A | N/A | Update drug; premedication |
| 25131 | Version 4.0; 30-July-2025 | N/A | Regimen comments; administration | Update drug; instructions |
| 24293 | Version 2.0; 13-October-2025 | N/A | Regimen comments; administration, prophylaxis, observation | Update drug; instructions, dose/form.
New Arm(s) |
| 24279 | Version 3.0; 10th December 2025 | N/A | N/A | Update drug; dose/form |
| RM 1238
MCCR |
Version 3.0; 16-March-2026 | N/A | N/A | Update drug; instructions |
| 25031 | Amendment 1.0; 11-August-2025 | N/A | N/A | Update drug; instructions, procurement |
| 24321 | Version 2.0; 09-April-2026 | N/A | Regimen comments; administration, prophylaxis | Update drug; instructions |
| 24005 | Version 4.0; 20th November 2025 | N/A | Regimen comments; Administration | Update drug; premedication |
| 24005 | Version 3.0; 10MAR2026 | N/A | N/A | Update drug; instructions |
| 23234 | Version 4.0; 10-Mar-2026 | N/A | Regimen comments; premedication | Update drug; procurement |
| 24246 | Version 3.0; 28-April-2026 | N/A | Regimen comments; Administration, premedication | Update drug; instructions |
| 22258 | Version 5.0; 16-March-2026 | N/A | Regimen comments; administration, prophylaxis, observation, premedication | Update drug; instructions, premedication, procurement |
| 25155 | PM v3.0; 21-May-2026 | N/A | N/A | Update drug; name |
| 24299 | Version 4.0; 30th January 2026 | N/A | Regimen comments; administration | Added; drug
Update drug; instructions |
| 24260 | PM v3.0, 18 Dec 2025 | N/A | N/A | Update drug; instructions |
| 24260 | PA2: 07 Nov 2025 | N/A | Regimen comments; administration, prophylaxis | Update drug; instructions, name |
| 22325 | Version 4.0; 22nd October 2025 | N/A | Regimen comments; administration, prophylaxis | Update drug; dose/form, instructions, frequency |
| 25178 | Version 10.0; 01-April-2026 | N/A | Regimen comments; administration | Update drug; instructions, name
Added; drug |
| 25157 | Amd 2 – Update Calcium Folinate | N/A | N/A | Added; drug |
| 25123 | Procurement update | N/A | N/A | Update drug; procurement |
| 25113 | Version 2.0; 22nd Sept 2025 | N/A | Regimen comments; administration, premedication | Update drug; instructions |
| 23304 | Version 12.0; 19th January 2026 | N/A | Regimen comments; administration | Update drug; instructions, procurement
New Arms |
| 25080 | Site Edits Request; Part 2 Regimens | N/A | N/A | Closed Arms
New Arms |
| 24306 | Version 5.0; 3-February-2026 | N/A | Regimen comments; administration, prophylaxis, premedication | Update drug; instructions, name |
| 24187 | Version 2.0; 5th February 2026 | N/A | N/A | Update drug; instructions, premedication |
| 24155 | Version 2.0; 13-March-2026 | N/A | Regimen comments; administration, premedication | Update drug; instructions, premedication |
| 24041 | PM v8.0; 04-May-2026 | N/A | N/A | Update drug; instructions |
| 25176 | Version 3.0; 02-April-2026 | N/A | Regimen comments; prophylaxis | Update drug; instructions, premedication |
| 25155 | Version 2.0; 24-March-2026 – | N/A | Regimen comments; administration | Update drug; instructions |
| 25017 | PM v3.0; 18-May-2026 | N/A | N/A | Update drug; admin/prep |
| 25021 | PM v4.0; 05-May-2026 | N/A | N/A | Update drug; instructions |
| 24264 | Site edits email | N/A | N/A | Update drug; dose/form, instructions |
| 24041 | Version 4.0; 30 July 2025 | N/A | Regimen comments; administration | N/A |
| 25227 | Version 2.0; 24-March-2026 | N/A | Regimen comments; prophylaxis | Update drug; instructions, frequency |
| 24310 | PM v12.0; 01-May-2026 | N/A | N/A | Update drug; frequency |
| 24250 | Version 4.0; 3rd November 2025 | N/A | Regimen comments; administration | Update drug; instructions, premedication |
| 24064 | Version 5.0; 06-November-2025 | N/A | Regimen comments; administration, prophylaxis | New Arms |
| 23243 | Version 3.0; 25-Feb-2026 | N/A | Regimen comments; administration, prophylaxis | Update drug; premedication |
| 24112 | Amendment 5,0; 19-Jan-2026 | N/A | Regimen comments; premedication | Update drug; name, premedication |
| 24190 | PAL; dated 1-April-2026 | N/A | N/A | Update drug; name |
| 25157 | PM v4: 16 Apr 2026 | N/A | N/A | Update drug; dose/form, instructions |
| 23116 | Version 7.0; 7-January-2026 | N/A | Regimen comments; administration | Update drug; instructions |
| 23116 | Version 7.0; 7-January-2026 | N/A | Regimen comments; administration | Update drug; instructions |
| 24189 | Version 2.0; 29-Jan-2026 | N/A | Regimen comments; prophylaxis | Update drug; instructions |
| 23059 | PM v3.0; 28-April-2026 | N/A | N/A | Update drug; instructions, name |