August 2026 SCRI Release Notes Copied
Updates were completed between July 17 and August 20, 2026.
Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens. For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 25220 | USOR 25220 LUN 658 Phase 3 ABBV-706 Q21D – v1.0 14NOV2025
USOR 25220 LUN 658 Phase 3 Lurbinectedin Q21D – v1.0 14NOV2025 USOR 25220 LUN 658 Phase 3 Topotecan IV Q21D – v1.0 14NOV2025 USOR 25220 LUN 658 Phase 3 Topotecan PO Q21D – v1.0 14NOV2025 |
| 24186 | USOR 24186 GYN 153 Phase 3 Arm 1 Sacituzumab Tirumotecan +/- Bevacizumab Q42D – 18JUL2025
USOR 24186 GYN 153 Phase 3 Arm 2 Bevacizumab Q42D – 18JUL2025 |
| 25234 | USOR 25234 GYN 177 Phase 3 Arm 1 R-DXd +/- Bevacizumab Q21D – 12JUN2026
USOR 25234 GYN 177 Phase 3 Arm 2 Bevacizumab Q21D – 12JUN2026 |
| 25179 | USOR 25179 GYN 172 Phase 3 Gemcitabine Q21D – v3 31OCT2025
USOR 25179 GYN 172 Phase 3 Gemcitabine Q28D – v3 31OCT2025 USOR 25179 GYN 172 Phase 3 INCB123667 Q28D – v3 31OCT2025 USOR 25179 GYN 172 Phase 3 Paclitaxel Q28D – v3 31OCT2025 USOR 25179 GYN 172 Phase 3 Pegylated Liposomal Doxorubicin Q28D – v3 31OCT2025 USOR 25179 GYN 172 Phase 3 Topotecan Q21D – v3 31OCT2025 USOR 25179 GYN 172 Phase 3 Topotecan Q28D – v3 31OCT2025 |
| 25019 | USOR 25019 GU 272 Phase 3 Arm 1 Sacituzumab Tirumotecan Q14D – 10JUN2026
USOR 25019 GU 272 Phase 3 Arm 2 Docetaxel Q21D – 10JUN2026 USOR 25019 GU 272 Phase 3 Arm 2 Paclitaxel Q21D – 10JUN2026 |
| 25243 | USOR 25243 GYN 178 Phase 3 Pembrolizumab (Maintenance) Q42D – 04JUN2026
USOR 25243 GYN 178 Phase 3 Pembrolizumab + Docetaxel + Carboplatin Q21D – 04JUN2026 USOR 25243 GYN 178 Phase 3 Pembrolizumab + Paclitaxel + Carboplatin Q21D – 04JUN2026 USOR 25243 GYN 178 Phase 3 PF-08634404 + Docetaxel + Carboplatin fb PF-08634404 Q21D – 04JUN2026 USOR 25243 GYN 178 Phase 3 PF-08634404 + Paclitaxel + Carboplatin fb PF-08634404 Q21D – 04JUN2026 |
| RM 1357
MCCR |
RM 1357 Phase 1/1b Arm A Part 1 Food Effect Substudy RMC-5127 – v2.0 19NOV2025
RM 1357 Phase 1/1b Arm A Part 1 RMC-5127 Q21D – v2.0 19NOV2025 RM 1357 Phase 1/1b Arm B Part 1 RMC-5127 + Daraxonrasib Q21D – v2.0 19NOV2025 RM 1357 Phase 1/1b Arm C Part 1 RMC-5127 + Cetuximab Q28D – v2.0 19NOV2025 |
| RM 1360
MCCR |
RM 1360 Phase 1 NEOK002 Q21D – 22FEB2026 |
| 25077 | USOR 25077 RM 1120 Phase 2 KB707 + Docetaxel Q21D – v3.1 01MAY2026 |
| 25165 | USOR 25165 LYM 289 Phase 4 Pirtobrutinib Q28D – 05MAR2026 |
| 26080 | USOR 26080 HN 48 Phase 2 Loading Phase Ficerafusp Alfa + Pembrolizumab Q21D – v1.0 20MAY2026
USOR 26080 HN 48 Phase 2 Maintenance Phase Arm A Ficerafusp Alfa + Pembrolizumab Q21D – v1.0 20MAY2026 USOR 26080 HN 48 Phase 2 Maintenance Phase Arm B Ficerafusp Alfa + Pembrolizumab Q21D – v1.0 20MAY2026 |
| 25223 | USOR 25223 LUN 655 Phase 2 Rinatabart Sesutecan Q21D – v2.0 01AUG2025 |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Drug Service Order Information | Updated Regimen Instructions | Other Changes |
| RM 1276
MCCR |
Version 5.0; 26-March-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 26056 | Procurement update: ROF and CA | N/A | N/A | Updated Drug; Instructions, Procurement |
| 26026 | PCL; dated 18-June-2026 | N/A | N/A | Update Drug; Frequency |
| 25146 | Version 4.0; 19-December-2025 | N/A | N/A | Update Drug; Instructions |
| 25146 | PCL; dated 13-July-2026 | N/A | N/A | Added Drug |
| 25146 | PCL; dated 17-June-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 25110 | PA Version 4.0; 24-Feb-2026
PM Version 2.0; 18-May-2026 |
N/A | Regimen Comments; Admin, Observation | Added Drug; Update Drug; Premedication, Instructions, Procurement; New Arm(s) |
| 25096 | Version 6.0; 13-May-2026 | N/A | Regimen Comments; Admin | Update Drug; Instructions, Name, Premedication |
| 25090 | Memo; 14-July-2026 | N/A | N/A | Closed Arm(s) |
| 25021 | Amendment 2.0; 29-April-2026
PM v5.0; 29-July-2026 |
N/A | Regimen Comments; Admin | Update Drug; Admin/Pre, Name |
| 25018 | Version 5.0; 10-March-2026 | N/A | N/A | Update Drug; Procurement, Supportive Care |
| 24328 | Version 4.0; 10-March-2026 | N/A | Regimen Comments; Admin | Update Drug; Instructions |
| 24310 | PCL; dated 12-March-2026 | N/A | Regimen Comments; Admin | Update Drug; Instructions |
| 24310 | Admin Letter; 17-June-2026 | N/A | Regimen Comments; Admin | Update Drug; Instruction |
| 24310 | Memo; 01-July-2026 | N/A | N/A | Added Drug |
| 24306 | PM v4.0; 15-July-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 24301 | Amendment 1.0; 8-May-2026 | N/A | Regimen Comments; Admin, Prophylaxis | Update Drug; Admin/Prep, Instructions, Added Drug |
| 24293 | PM v2.0;03-July-2026
PM v02; 25-June-2026 |
N/A | N/A | Update Drug; Dose/Form, Name |
| 24256 | Version 4.0: 05 December 2025 | N/A | Regimen Comments; Premedication | Added Drug; Update Drug; Instructions |
| 24240 | PA v10.0: 03-Feb-2026
PM v7.0: 26-Jan-2026 |
N/A | Regimen Comments; Admin | Update Drug; Dose/Form, Instructions, Premedication, Procurement
New Arm(s) |
| 24232 | Procurement update: ROF released | N/A | N/A | Update Drug; Procurement |
| 24221 | Version 4.0; 5-October-2025 | N/A | Regimen Comments; Admin | N/A |
| 24209 | PAL; 10-March-2026 | N/A | Regimen Comments; Prophylaxis | Added; Drug |
| 24171 | Version 4.0; 22-April-2026 | N/A | Regimen Comments; Admin, Premedication | Update Drug; Instructions, Name
Added Drug |
| 23341 | Amendment 4.0; 15-April-2026 | N/A | N/A | Updated Drug; Admin/Prep, Supportive Care |
| 23335 | PM v2.0; 06-July-2026 | N/A | N/A | Update Drug; Admin/Prep, Dose/Form, Instructions |
| 23304 | PM v7.0; 05-Aug-2026 | N/A | N/A | Update Durg; Admin/Prep |
| 23292 | Version 21.1; dated 21-May-2026 PM Version 13.0; 26 JUN 2026 | N/A | Regimen Comments; Prophylaxis | Update Drug; Dose/Form, Instructions |
| 23265 | Version 2.2; 15 Sept 2025 | N/A | Regimen Comments; Prophylaxis | Update Drug; Instructions |
| 23254 | Amendment 7; 15-May-2025 | N/A | Regimen Comments; Admin, Prophylaxis, Observation, Premedication | Update Drug; Dose/Form, Procurement, Supportive Care |
| 23122 | Version 4.0; 16-June-2026 | N/A | Regimen Comments | Update Drug; Instructions |
| 23094 | Version 11.0; 06-April-2026 | N/A | Regimen Comments; Admin, Observation, Premedication | Update Drug; Admin/Prep, Dose/Form, Instructions, Premedication |
| 23079 | Version 2.0; 17-November-2025 | N/A | Regimen Comments; Premedication | Added Drug; Update Drug; Dos/Form |
| 22026 | Version 9.0; 16-March-2026;
PM v9.0; 30-April-2026 |
N/A | Regimen Comments; Admin, Premedication | Update Drug; Dose/Form, Instructions, Premedication, Procurement |
| 22002 | Version 5.0; 13-Oct-2025
PM v9.0; 10-March-2026 |
N/A | Regimen Comments; Admin, Prophylaxis, Premedication | Update Drug; Instructions |
| RM 1360
MCCR |
Procurement Change | N/A | N/A | Update Drug; Procurement |