August 2025 SCRI Release Copied
SCRI Trials and Trial Regimen Updates
The following updates were completed between July 25 and August 21. Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens.
For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 24265 | USOR 24265 LYM 246 Phase 2 Obinutuzumab + Glofitamab + Gemcitabine + Oxaliplatin Q21D |
| 25049 | USOR 25049 LUN 618 Phase 2 Zelenectide Pevedotin Q21D – v2.0 19MAR2025 |
| 24021 | USOR 24021 LUN 561 Phase 2 Adjuvant Cemiplimab Q42D 17MAY2024
USOR 24021 LUN 561 Phase 2 Neoadjuvant Cemiplimab + Paclitaxel + Carboplatin Q21D 17MAY2024 USOR 24021 LUN 561 Phase 2 Neoadjuvant Cemiplimab + Paclitaxel + Cisplatin Q21D 17MAY2024 USOR 24021 LUN 561 Phase 2 Neoadjuvant Cemiplimab + Pemetrexed + Carboplatin Q21D 17MAY2024 USOR 24021 LUN 561 Phase 2 Neoadjuvant Cemiplimab + Pemetrexed + Cisplatin Q21D 17MAY2024 USOR 24021 LUN 561 Phase 2 Neoadjuvant REGN7075 + Cemiplimab + Paclitaxel + Carboplatin Q21D 16MAY2024 USOR 24021 LUN 561 Phase 2 Neoadjuvant REGN7075 + Cemiplimab + Pemetrexed + Carboplatin Q21D 16MAY2024 USOR 24021 LUN 561 Phase 2 Neoadjuvant REGN7075 + Cemiplimab + Pemetrexed + Cisplatin Q21D 16MAY2024 |
| 24306 | USOR 24306 GYN 147 Phase 3 Induction Pembrolizumab + Paclitaxel + Carboplatin Q21D – 30JAN2025
USOR 24306 GYN 147 Phase 3 Maintenance Arm A Sac-TMT + Pembrolizumab Q42D – 30JAN2025 USOR 24306 GYN 147 Phase 3 Maintenance Arm B Pembrolizumab Q42D – 30JAN2025 USOR 24306 GYN 147 Phase 3 Second Course Pembrolizumab Q42D – 30JAN2025 USOR 24306 GYN 147 Phase 3 Subsequent Treatment Arm A Sac-TMT + Pembrolizumab Q42D – 30JAN2025 USOR 24306 GYN 147 Phase 3 Subsequent Treatment Arm B Sac-TMT Q42D – 30JAN2025 |
| 24246 | USOR 24246 GI 387 Phase 2 Fruquitinib + FOLFIRI Q28D – 26JUN2025
USOR 24246 GI 387 Phase 2 Safety Lead-In Fruquintinib + FOLFIRI Q28D – 26JUN2025 |
| 25017 | USOR 25017 BRE 468 Phase 1b/2 Disitamab Vedotin Q14D – 31MAR2025 |
| MCCR (RM 1238) | RM 1238 Phase 1a Induction DR-0202 (D1,15) Q28D – 24APR2025
RM 1238 Phase 1a Induction DR-0202 (D1,8,15) Q28D – 24APR2025 RM 1238 Phase 1a Maintenance DR-0202 Q21D – 24APR2025 RM 1238 Phase 1a Maintenance DR-0202 Q28D – 24APR2025 |
| 24328 | USOR 24328 GI 406 Phase 2 Telisotuzumab Adizutecan Q21D – v2.0 24FEB2025 |
| 25042 | USOR 25042 BRE 467 Phase 3 Capivasertib + Fulvestrant Q28D v1.0 30Jan2025
USOR 25042 BRE 467 Phase 3 RLY-2608 + Fulvestrant Q28D v1.0 30Jan2025 |
| 25032 (MCCR) | USOR 25032 GYN 157 Phase 2 TILT-123 + Pembrolizumab D1-70 – v9 12FEB2025
USOR 25032 GYN 157 Phase 2 TILT-123 + Pembrolizumab Q21D (D71+) – v9 12FEB2025 |
| 23341 | USOR 23341 LUN 584 Phase 3 Docetaxel Q21D – v2.1 05MAY2025
USOR 23341 LUN 584 Phase 3 RMC-6236 Q21D – v2.1 05MAY2025 |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Regimen Instructions | Other Changes |
| 21468 | Version 4.0, 03JUN2025 | N/A | N/A |
| 22067 | N/A | N/A | Updated Drug; Admin/Prep |
| 22201 | Site Request | N/A | Added Drug |
| 22273 | Memo, 19 June 2025 | N/A | Closed Arm(s) |
| 23084 | PA v5.0: 28 Feb 2025 | Regimen Comments; Updated Amin, Prophylaxis | Updated Drug, Admin Prep, Premedication |
| 23129 | Version 5.0, 29APR2025 | N/A | Updated Drug Instruction |
| 23141 | PA08: 01 Apr 2025 | Regimen Comments; Prophylaxis | N/A |
| 23166 | PA v.10.0; 12 May 2025 | N/A | Reference Change |
| 23244 | Memo, 25 June 2025 | N/A | N/A |
| 23297 | IPIM v4: 11 Jun 2025 | N/A | Updated Drug; Admin/Prep |
| 23309 | Amendment 7, 30APR2025 | Regimen Comments; Prophylaxis | Updated Drug; Premedication |
| 23337 | PM V3.0: 03 Jul 2024 | N/A | Added Drug, Updated Drug, Admin/Prep |
| 23340 | PA v3.0: 29 May 2025 | Regimen Comments; Admin | Updated Drug Instructions |
| 24026 | PA V3.1: 12Feb2025 See PM V3 | N/A | Updated Drug Instruction |
| 24030 | PA2: 11 Dec 2024 | Regimen Comments; Administration | N/A |
| 24089 | PA v5.0: 28Jan2025 | N/A | Updated drug instructions |
| 24100 | Version 4.0, 30APR2025 | N/A | Updated Drug; Admin/Prep |
| 24112 | Site Edits | N/A | Updated Drug Instructions |
| 24145 | PA6.0: 18 Feb 2025 | N/A | Updated Drug; Dose/Form, Updated drug instructions |
| 24171 | PA 3, 12MAR2025 | Regimen Comments; Prophylaxis, Observation | Updated Drug Instructions |
| 24224 | PM v1.1: 28 Mar 2025 | N/A | Updated Drug; Admin/prep |
| 24224 | PA V1.1, 24APRIL2025 PA V1, 26FEB2025 | New Regimen, Regimen Comments; Prophylaxis | Updated Drug, Admin/Prep, Instructions, and Frequency |
| 24250 | PM v4: 02 Jun 2025 | N/A | Update drug instructions |
| 24288 | Version 5.0, 10JUN2025 | N/A | Updated drug instruction |
| 24288 | Version 2.1, 09APR2025 | N/A | Updated Drug; Admin/Prep |