April 2025 SCRI Release Copied
SCRI Trials and Trial Regimen Updates
The following updates were completed between March 21, 2025, through April 18, 2025. Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens. For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 24101 | USOR 24101 AUTO 03 Phase 1 CB-010
USOR 24101 AUTO 03 Phase 1 Lymphodepletion Cyclophosphamide D-4,-3 + Fludarabine D-5,-4,-3 |
| 24139 | USOR 24139 GYN 138 Phase 3 Gemcitabine D1,8,15 Q28D
USOR 24139 GYN 138 Phase 3 Paclitaxel D1,8,15 Q28D USOR 24139 GYN 138 Phase 3 Pegylated Liposomal Doxorubicin Q28D USOR 24139 GYN 138 Phase 3 Rina-S (Rinatabart Sesutecan, PRO1184) Q21D USOR 24139 GYN 138 Phase 3 Topotecan D1-5 Q21D USOR 24139 GYN 138 Phase 3 Topotecan IV D1,8,15 Q28D |
| 24174 | USOR 24174 LYM 245 Phase 1 ABBV-291 Q28D |
| 24170 | USOR 24170 HN 39 Phase 2 Ficerafusp alfa or Placebo + Pembrolizumab Q21D |
| 24224 | USOR 24224 AML 77 Phase 1 Consolidation BL-M11D1 Q28D
USOR 24224 AML 77 Phase 1 Induction BL-M11D1 Q28D USOR 24224 AML 77 Phase 1 Maintenance BL-M11D1 Q28D |
| 24259 | USOR 24259 LUN 585 Phase 3 Ivonescimab or Pembrolizumab Q21D |
| 24288 | USOR 24288 BRE 454 Phase 2 Zelenectide Pevedotin (BT8009) D1,8 Q21D |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Regimen Instructions | Other Changes |
| 22088 | N/A | N/A | Updated infusion time wording |
| 22095 | Amendment 8: 31 Oct 2024 | N/A | Updated drug instruction for missed doses |
| 22244 | Amendment 02: 29 Oct 2024. | Updated prophylaxis | Updated regimen title |
| 22201 | Amendment 3 (Version 4.0): 10 Sep 2024 | N/A | Added weight instruction |
| 20345 | Version 6.0: 26 Nov 2024. | Updated premedication instruction | N/A |
| 23245 | Amendment 02: 24 Dec 2024. | N/A | Updated drug instruction |
| 23284 | Protocol version: 2.0: 04 Nov 2024. | Updated drug name | N/A |
| 23307 | Master and Subprotocol B Amendment 2: 06 Aug 2024 | Updated premedication | Updated drug instruction |
| 22258 | Amendment 4: 22 Jan 2025. | N/A | Updated drug infusion window |
| 24106 | Amendment 5.0: 06 Nov 2024. | N/A | N/A |
| 23203 | Version 3.0: 16 Jan 2025. | N/A | N/A |
| 23084 | N/A | Updated drug name | N/A |
| 23083 | Version 4.0: 03 Dec 2024. | N/A | Updated administration instruction |
| 24007 | Version 2.0: 19 Dec 2024. | N/A | N/A |
| 23288 | Amendment 2 Version 3: 13 Dec 2024. | N/A | Updated administration time |
| 23172 | N/A | N/A | Added drug placeholder |
| 22298 | Amendment 9: 01 November 2024. | N/A | Updated administration instruction |
| 22067 | Version 5.4: 10 Mar 2025. | N/A | Updated carboplatin dose |
| 23252 | Version 3.0 (Amendment 2): 21 Feb 2025. | N/A | Added new cohort. Updated drug instruction |
| 23252 | N/A | N/A | Updated stability |
| 23048 | Version 5.0: 29 Nov 2024. | Updated administration | N/A |