October 2026 SCRI Release Notes Copied
Updates were completed between September 18, 2026 and October 15, 2026.
Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens.
For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 23287 | USOR 23287 GYN 137 Phase 3 BNT323 Q21D – v6.0 12NOV2025
USOR 23287 GYN 137 Phase 3 Docetaxel Q21D – v6.0 12NOV2025 USOR 23287 GYN 137 Phase 3 Doxorubicin Q21D – v6.0 12NOV2025 USOR 23287 GYN 137 Phase 3 Paclitaxel Q28D – v6.0 12NOV2025 |
| 26064 | USOR 26064 BRE 486 Phase 3b Maintenance Trastuzumab + Pertuzumab + Endocrine Therapy + Palbociclib Q28D – v1.0 18MAY2026
USOR 26064 BRE 486 Phase 3b Retreatment T-DXd Q21D – v1.0 18MAY2026 USOR 26064 BRE 486 Phase 3b Upfront Treatment T-DXd + Pertuzumab Q21D – v1.0 18MAY2026 |
| 26103 | USOR 26103 GU 332 Phase 2 JNJ-101556143 Q28D – 13JUL2026 |
| 26031 | USOR 26031 MULTI 118 Phase 2 MK-2010 + Belzutifan Q21D – 26JUN2026
USOR 26031 MULTI 118 Phase 2 MK-2010 + FOLFOX Q14D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 MK-2010 + FOLFOX Q42D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 MK-2010 + Gemcitabine + Cisplatin Q21D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 MK-2010 + Nab-Paclitaxel + Carboplatin Q21D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 MK-2010 + Paclitaxel + Carboplatin Q21D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 MK-2010 + Pemetrexed + Carboplatin Q21D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 MK-2010 + Pemetrexed + Cisplatin Q21D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 MK-2010 Q21D – 26JUN2026 USOR 26031 MULTI 118 Phase 2 Pembrolizumab + FOLFOX Q42D – 26JUN2026 |
| 25189 | USOR 25189 GYN 174 Phase 3 Doxorubicin Q21D – 27APR2026
USOR 25189 GYN 174 Phase 3 Mocertatug Rezetecan Q21D – 27APR2026 USOR 25189 GYN 174 Phase 3 Paclitaxel Q28D – 27APR2026 |
| 25170 | USOR 25170 BRE 477 Phase 2 All Arms Inavolisib + Ribociclib + Letrozole (Cycle 6) Q21D – v2 26SEP2025
USOR 25170 BRE 477 Phase 2 Arm A Inavolisib + Ribociclib + Letrozole Q28D – v2 26SEP2025 USOR 25170 BRE 477 Phase 2 Arm B Inavolisib + Letrozole fb Inavolisib + Ribociclib + Letrozole Q28D – v2 26SEP2025 USOR 25170 BRE 477 Phase 2 Arm C Ribociclib + Letrozole fb Inavolisib + Ribociclib + Letrozole Q28D – v2 26SEP2025 |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Drug Service Order Information | Updated Regimen Instructions | Other Changes |
| 21462 | Site request for DTH Test clarification | N/A | Regimen Comments; Admin | New Arm(s) |
| 22320 | Version 5.0; 22 Sept 2025 | N/A | Regimen Comments; Admin, Observation | Update Drug; Admin/Prep, Supportive Care |
| 23203 | Version 5.0; 25 October 2025 | N/A | Regimen Comments; Admin | Update Drug; Admin/Prep
New Arm(s) |
| 23288 | Version 6.0; 06 November 2025
PM v6.0; 03-October-2025 |
N/A | Regimen Comments; Prophylaxis | Update Drug; Admin/Prep |
| 23289 | Version 3.6; 17-March-2026 | N/A | Regimen Comments; Admin, Prophylaxis | Update Drug; Admin/Prep, Frequency |
| 23328 | Version 4.0; 20-March-2026 | N/A | N/A | Update Drug; Dose/Form |
| 24041 | Version 5.0; 20-Feb-2026 PM v9.0; 15-July-2026 | N/A | Regimen Comments; Admin | Update Drug; Admin/Prep |
| 24185 | PM v6.0; 01-Sept-2026 | N/A | N/A | Update Drug; Dose/Form |
| 24187 | PM v5.0; 31-Aug-2026 | N/A | N/A | Update Drug; Admin/Prep, Dose/Form |
| 24196 | Version 5.0; 07-April-2026 | N/A | Regimen Comments; Prophylaxis, Premedication | Update Drug; Supportive Care |
| 24199 | Version 3.0; 08-April-2026
PM Version 4.0; 31-Mar-2026 |
N/A | Regimen Comments; Admin, Prophylaxis, Observation | Update Drug; Admin/Prep, Supportive Care |
| 24270 | Version 3.0; 31-Oct-2025 | N/A | Regimen Comments; Admin, Prophylaxis | Update Drug; Admin/Prep, Frequency |
| 24276 | Version 4.0; 24-April-2026
PM Version 3.0: 01-Sep-2026 |
N/A | Regimen Comments; Admin, Prophylaxis, Premedication | Update Drug; Admin/Prep, Supportive Care |
| 24289 | Version D; 23-June-2026 | N/A | Regimen Comments; Admin | N/A |
| 24292 | PM v4.0; 30-April-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 24306 | Version 6.0; 28-July-2026 | N/A | Regimen Comments; Admin, Prophylaxis | Added; Drug
Update Drug; Admin/Prep New Arm(s) |
| 24314 | Version 3.0; 23-June-2026 | N/A | Regimen Comments; Admin, Premedication | N/A |
| 24314 | Version 4.0; 20-Aug-2026 | N/A | Regimen Comments | N/A |
| 25009 | Version 7.0; 25-Feb-2026
Memo; dated 27-Feb-2026 |
N/A | Regimen Comments; Admin, Prophylaxis, Premedication | Update Drug; Admin/Prep, name, Supportive Care |
| 25077 | Version 4.0; 14-Aug-2026
Version 4.1; 17-Sept-2026 |
N/A | Regimen Comments; Premedication | Update Drug; Admin/Prep |
| 25086 | Version 7.0; 13-March-2026
PM v7.0; 17-June-2026 |
N/A | Regimen Comments; Prophylaxis, Observation | Update Drug; Admin/Prep, Name, Procurement
Added; Drug New Arm(s) |
| 25181 | Version 3.0; 2-June-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 25229 | PM v3.0; 31-Aug-2026 | N/A | N/A | Update Drug; Admin/Prep |
| RM 1204
MCCR |
Version 4.0; 09-April-2026 | N/A | Regimen Comments; Observation | Added; Drug
Update Drug; Admin/Prep |
| RM 1306
MCCR |
Version 5.0; 10-Aug-2026 | N/A | Regimen Comments; Premedication | Update Drug; Supportive Care |
| 23304 | Memo; 28-July-2026
Memo on P1 Squamous NSCLC Backfill, 04Aug2026 |
N/A | N/A | New Arm(s) |
| 25176 | Version 4.0; 08-July-2026
Version 5.0; 13-Aug-2026 PM v4.0; 15-Apr-2026 PM v5.0; 21-Sep-2026 |
N/A | Regimen Comments; Admin | Added; Drug
Update Drug; Admin/Prep New Arm(s) |
| 26022 | Drug Procurement Change | N/A | N/A | Update Drug; Procurement |
| 25035 | Version 2.0; 11-May-2026 | N/A | Regimen Comments; Prophylaxis, Premedication | Update Drug; Admin/Prep, Supportive Care |
| 24170 | Version 3.0; 10-June-2026 | N/A | Regimen Comments; Premedication | Update Drug; Admin/Prep |
| RM 1204
MCCR |
Convert inpatient regimen to outpatient regimen | N/A | N/A | New Arm(s) |
| 25028 | Version 3.0; 01-May-2026 | N/A | Regimen Comments; Prophylaxis | Update Drug; Admin/Prep |
| 25090 | Version 4.0; 27-July-2026 | N/A | Regimen Comments; Observation | Update Drug; Admin/Prep |
| 25090 | PM_v2_22Jan 2026 | N/A | N/A | Update Drug; Admin/Prep |
| 24198 | Version 6.0; 04-June-2026 | N/A | Regimen Comments; Admin | Update Drug; Admin/Prep |
| 25180 | Version 2.0; 06-March-2026 | N/A | Regimen Comments; Prophylaxis, Premedication | Update Drug; Supportive Care |
| 23240 | Amendment 11.0; 25-Aug-2026 Amendment 10.0; 09-July-2026 Amendment 9; 10-Jun-2026 | N/A | Regimen Comments; Admin, Prophylaxis | Update Drug; Admin/Prep |
| 23122 | Version 5.0; 11-Sept-2026 | N/A | Regimen Comments; Admin | N/A |
| 25190 | Amendment 3.0; 07-April-2026 | N/A | Regimen Comments; Admin, Prophylaxis | Update Drug; Supportive Care |
| 25030 | Version 3.0; 19-Jan-2026 | N/A | Regimen Comments; Admin, Prophylaxis, Observation | Update Drug; Admin/Prep, Dose/Form |
| 25006 | Version 2.0; 22-October-2025 | N/A | Regimen Comments; Admin, Prophylaxis, Premedication | Update Durg; Supportive Care |
| 24110 | Version 4.0; 02-July-2026 | N/A | Regimen Comments; Premedication | Update Drug; Admin/Prep, Dose/Form, Supportive Care |
| 24110 | PM v6.0; 31-July-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 25086 | PM v8.0; 17-Aug-2026 | N/A | N/A | Update Drug; Admin/Prep |
| 25139 | Drug sourcing update | N/A | N/A | Update Drug; Procurement |