April 2026 SCRI Release Notes Copied
SCRI Trials and Trial Regimen Updates
The following updates were completed between March 20 – April 16, 2026. Sarah Cannon Research Institute now manages all SCRI/USOR trials and trial regimens.
For questions about these trials and regimens, please contact SCRIiKMEMRedits@McKesson.com.
New Builds Completed
| Study Number | Notes for New Build |
| 25227 | USOR 25227 GI 446 Phase 2 PF-08634404 + Capecitabine + Oxaliplatin (CAPOX) Q21D – 27JAN2026
USOR 25227 GI 446 Phase 2 PF-08634404 + Fluorouracil + Leucovorin + Oxaliplatin (mFOLFOX6) Q28D – 27JAN2026 |
| 25105 | USOR 25105 LUN 633 Phase 2 Pre-Randomization Osimertinib Q21D – v1.0 15JUL2025
USOR 25105 LUN 633 Phase 2 Telisotuzumab Adizutecan Q21D – v1.0 15JUL2025 |
| 25121 | USOR 25121 LUN 636 Phase 2 Docetaxel Q21D – v3.0 31OCT2025
USOR 25121 LUN 636 Phase 2 Petosemtamab + Docetaxel Q21D – v3.0 31OCT2025 USOR 25121 LUN 636 Phase 2 Petosemtamab + Pembrolizumab Q42D – v3.0 31OCT2025 |
| 25225 | USOR 25225 GI 447 Phase 3 INCB161734 or Placebo + Fluorouracil + Leucovorin + Irinotecan + Oxaliplatin Q28D – v1 22DEC2025
USOR 25225 GI 447 Phase 3 INCB161734 or Placebo + Nab-Paclitaxel + Gemcitabine Q28D – v1 22DEC2025 |
| 25216 | USOR 25216 GI 441 Phase 3 INCA33890 or Placebo + Fluorouracil + Leucovorin + Oxaliplatin + Bevacizumab Q14D – 03NOV2025 |
| 25058 | USOR 25058 MM 202 Phase 2 JNJ-79635322 Q28D – 11NOV2025
USOR 25058 MM 202 Phase 2 JNJ-79635322 Step-Up Dose – 11NOV2025 |
| 25219 | USOR 25219 GI 444 Phase 3 Arm 1 Precemtabart tocentecan Q21D – v3.0 23FEB2026
USOR 25219 GI 444 Phase 3 Arm 2 Precemtabart tocentecan + Bevacizumab Q21D – v3.0 23FEB2026 USOR 25219 GI 444 Phase 3 Arm 3 Trifluridine/Tipiracil + Bevacizumab Q28D – v3.0 23FEB2026 |
Updated Reference Information
| Study Number | Updated Reference Information | Updated Drug Service Order Information | Updated Regimen Instructions | Other Changes |
| RM 1238
MCCR |
Version 2.0; 29th January 2026 | N/A | N/A | Update drug; admin/prep |
| RM 1275
MCCR |
Version 5.0; 5-January-2026 | N/A | N/A | Update drug; instructions |
| RM 1275
MCCR |
PCL; 09-March-2026 | N/A | N/A | Update drug; instructions |
| 25091 | Version 2.0; 5th December 2025 | N/A | Regimen comments; prophylaxis, observation | Update drug; instructions |
| 25044 | PCL; 23-Feb-2026 | N/A | N/A | Update drug; instructions |
| 24262 | PA v3.0: 07 Nov 2025 | N/A | N/A | New Arms |
| 24215 | Version 4.0; 7th November 2025 | N/A | Regimen comments; administration | N/A |
| 24151 | Version 3.0; 20th December 2025 | N/A | Regimen comments; Premedication | Update drug; instructions |
| 24119 | PA2.0: 07 Mar 2025 | N/A | N/A | Update drug; admin/prep, instructions |
| 24059 | Version 3.0; 24th October 2025 | N/A | N/A | Added drug Update drug; instructions |
| 23341 | Version 3.0; 12 Sept 2025 | N/A | Regimen comments; Prophylaxis | Update drug; name, premedication |
| 23302 | Version 4.0; 11 Sept 2025 | N/A | Regimen comments; premedication | Update drug; admin/prep |
| 23271 | Version 2.0; 21st June 2025 | N/A | N/A | Update drug; admin/prep |
| 23120 | PA v9.0; 11 July 2025
Memo; 02 July 2025 |
N/A | Regimen comments; administration | Update drug; instructions |
| 23099 | Version 4.0; 12 November 2025 | N/A | Regimen
Comments; Premedication |
Update drug; admin/prep, dose/form, premedication |
| 23095 | Version 6.0; 14th January 2026 | N/A | Regimen comments; Administration | Update drug; instructions |
| 25044 | Version 2.0; 19th December 2025 | N/A | N/A | Update drug; instructions |
| 23309 | PM v3.0; dated 7-Jan-2026
PM v5.0; date 7-Jan-2026 PM v1.0; dated 3-Jan-2026 PM v2.0; dated 4-August-2025 |
N/A | N/A | Update drug; instructions |
| 24070 | SRC Memo; 31-March-2026 | N/A | N/A | Update drug; instructions |
| 24185 | Protocol v3.0; 20th August 2025 | N/A | Regimen comments; administration | Update drug; instructions |
| 25007 | Version 1.0; 02 Sept 2025 | N/A | Regimen comments; administration | Update drug; instructions |
| 23095 | PM v6.0; 23-March-2026 | N/A | N/A | Update drug; instructions |
| 23031 | Memo Update Arm C | N/A | Regimen comments; administration, observation | Update drug; instructions, premedication, dose/form |
| RM 1324
MCCR |
Site Request: Need Backfill Cohort Q3W | N/A | N/A | New Arms |
| 23251 | PA v3.0; 11th June 2025 | N/A | Regimen comments; administration | Update drug; instructions |
| 23335 | PM v1.0, dated 2024 | N/A | N/A | Update drug; dose/form, instructions |